Reactions of 1-Aza-1,3-butadienes. A Convenient Synthesis of N-Benzyl-1,4-dihydropyridines.
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چکیده
منابع مشابه
SYNTHESIS OF 4-(1-BENZYL-5-IMIDAZOLYL)-1,4-DIHYDROPYRIDINES
The o-nitrophenyl group at position 4 of dihydropyridine of nifedipine analogues was replaced with 2-alkylthio-1-benzyl-5-imidazolyl substituent. Starting from dihydroxyacetone 2-alkythio-1-benzyl- 5-formyl imidazole (3) was first synthesized which was subsequently used in synthesizing symmetrical (5a-f) and asymmetrical (6a,b) dihydropyridines. Primarily pharmacological studies of the title co...
متن کاملsynthesis of 4-(1-benzyl-5-imidazolyl)-1,4-dihydropyridines
the o-nitrophenyl group at position 4 of dihydropyridine of nifedipine analogues was replaced with 2-alkylthio-1-benzyl-5-imidazolyl substituent. starting from dihydroxyacetone 2-alkythio-1-benzyl- 5-formyl imidazole (3) was first synthesized which was subsequently used in synthesizing symmetrical (5a-f) and asymmetrical (6a,b) dihydropyridines. primarily pharmacological studies of the title co...
متن کاملREACTIONS OF DIHYDROPYRIDINES WITH BENZYNE
Reactions of 1 ,Zdihydropyridines (la-c) and 1,4-dihydropyridines (2a-c) in the presence of benzyne (3) under thermal conditions, and in the case of (2c) under photochemical conditions, have been investigated. Benzyne acts as an oxidizing agent to convert dihydropyridine (la) and (2a) to the corresponding pyridine (4) or adds as a dienophile to (lb-c).
متن کاملsynthesis and antihypertensive activity of novel 4-[1-(4-x-benzyl)-5-imidazolyl] dihydropyridines in rat
a series of 1,4-dihydropyridine calcium channel blockers bearing 1-(4-x -benzyl)-5-imidazolyl substituent at 4 position (5a-e) (x=h, f) were synthesized and tested for antihypertensive activity in desoxycorticosterone acetate (doca)-induced hypertension in rats. amlodipine was used as the standard dihydropyridine. all compounds tested showed lower antihypertensive activity than that of amlodipi...
متن کاملConvenient method for synthesis of a carbon-14 analogue of DL-Phenyl alanine
DL-Phenyl alanine labeled with carbon-14 in the α-position has been synthesized from ethyl[2-14C] acetate as part of a 6-step sequence.
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ژورنال
عنوان ژورنال: Acta Chemica Scandinavica
سال: 1989
ISSN: 0904-213X
DOI: 10.3891/acta.chem.scand.43-0618